JSM 2005 - Toronto

Abstract #304745

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Activity Number: 474
Type: Topic Contributed
Date/Time: Thursday, August 11, 2005 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Statistical Science
Abstract - #304745
Title: A Bayesian Phylogenetic Method to Identify Multiple Recombination Events Among Recombinant Sequences with Apparent Similar Mosaic Structure
Author(s): Fang Fang*+ and Karin Dorman and Marc A. Suchard and Vladimir N. Minin
Companies: Iowa State University and Iowa State University and University of California, Los Angeles and University of California, Los Angeles
Address: Science II, Room 503, Ames, IA, 50011, USA
Keywords: Bayesian ; phylogenetic ; monophyletic ; recombination ; hotspots
Abstract:

Recombination in retroviruses can synthesize unique mosaic viruses that might have selective advantages over the parental genomes. Many recombinant viruses have been sequenced, and many recombinants are observed to share the same mosaic structure. It has been hypothesized that observing recombinants with similar structure indicates certain regions in the genome undergo recombination more often than others. However, it is more commonly assumed that these sequences result from a single recombination event that has subsequently spread through a population either by chance or after selection. Only sequences confirmed to descend from different recombinant events are valid for identifying recombinant hotspots. A Bayesian phylogenetic method is introduced to identify, given appropriate reference sequences, whether two similar recombinants descend from multiple recombination events. Two recombinants descending from the same event should be monophyletic when compared against any reference sequences. To test for such monophyletic structure, we employ a modified prior structure on an existing dual multiple change-point model (MCP).

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