JSM 2005 Online Program

Abstract #304637

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	237
Type:	Contributed
Date/Time:	Tuesday, August 9, 2005 : 8:30 AM to 10:20 AM
Sponsor:	Section on Statistics in Epidemiology
Abstract - #304637
Title:	Genetic Misclassification and Gene-environment Interactions in Case-control Studies
Author(s):	Christine Spinka*+ and Raymond J. Carroll and Nilanjan Chatterjee
Companies:	University of Missouri, Columbia and Texas A&M University and National Cancer Institute
Address:	146 Middlebush Hall, Columbia, MO, 65211, United States
Keywords:	Case-control Studies ; Gene-Environment Interactions ; Genetic Epidemiology ; Logistic Regression ; Retrospective Studies ; Semiparametric Methods
Abstract:	Epidemiologic studies investigating the interaction between genetics and environmental factors have become increasingly common in recent years. Sometimes data for these studies are collected using a case-control study design. In this setting, we utilize a logistic regression model to estimate the probability of disease and include covariates for the effects of genetic factors, environmental factors, and their interaction. We develop a semiparametric method to estimate these parameters in the presence of genetic misclassification, provided that some information about the rate of misclassification can be obtained. We illustrate the effectiveness our method using a simulation study.

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