JSM 2005 Online Program

Abstract #304602

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	98
Type:	Contributed
Date/Time:	Monday, August 8, 2005 : 8:30 AM to 10:20 AM
Sponsor:	Biometrics Section
Abstract - #304602
Title:	Distributional Aspects of P-values and Their Use in MultipleTesting Situations
Author(s):	Xiaojun Hu*+ and Gary Gadbury
Companies:	University of Missouri, Rolla and University of Missouri, Rolla
Address:	2017 Forum Dr Apt F, Rolla, MO, 65401, United States
Keywords:	P-value ; microarray ; gene expression
Abstract:	Distributional properties of a P-value, as a random variable, have found use in multiple testing applications such as those that occur when analyzing data from microarrays. Under the null hypothesis, the distribution of a P-value is uniform on the interval [0,1], providing the correct distribution of the test statistic was used to compute the P-value. When the alternative hypothesis is true, the distribution depends on other factors, such as effect size and sample size. This paper explores distributional properties of a P-value obtained from an incorrect reference distribution and the implications for multiple testing situations. Also considered is the joint distribution of correlated P-values and the effect of correlation on conclusions from multiple tests.

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