JSM 2005 - Toronto

Abstract #304548

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 184
Type: Topic Contributed
Date/Time: Monday, August 8, 2005 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #304548
Title: Functional Sensitivity: Definition, Theory, and Evaluation Method
Author(s): Patrick Meyers*+ and Suha Sari
Companies: Abbott Laboratories and Abbott Laboratories
Address: Dept 04K8 BLDG AP31, Abbott Park, IL, 60064-3537, United States
Keywords: Functional ; Sensitivity ; Transformation ; Regression ; LoQ ; LoD
Abstract:

This presentation will cover definitions of common assay performance measurements for low-concentration values in quantitative assays. The terms Limit of Detection (LoD), Limit of Blank (LoB), Limit of Quantitation (LoQ), and Analytical Sensitivity will be discussed. A short history and a definition of Functional Sensitivity will be presented. Similarities and differences between Functional Sensitivity and LoQ will be explored. Different methods for calculation of Functional Sensitivity will be given and the results from visual and regression analysis will be compared in a series of examples.

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Revised March 2005