JSM 2005 Online Program

Abstract #304427

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	32
Type:	Contributed
Date/Time:	Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #304427
Title:	Statistical Comparison of Antimicrobial Susceptible Test Methods
Author(s):	Shailendra N. Banerjee*+
Companies:	Centers for Disease Control and Prevention
Address:	5375 Country Lake Court, Lilburn, GA, 30047, United States
Keywords:	Sensitivity ; Specificity ; Molecular ; Borderline
Abstract:	This study aims to develop a single index to measure the efficiency of an antimicrobial susceptibility method. Several methods will be ranked in order of efficiency in comparison with the gold standard, the presence of mecA gene. One hundred sixteen isolates of Staphylococcus aureus with borderline susceptibility to oxacillin were tested by various susceptibility methods to determine the accuracy of each method to detect oxacillin resistance. These methods were molecular, automated, and manual; some of the manual methods were tested for 18 and 24 hours and counted as separate methods. A total of 13 methods, labeled A through M, were compared to a molecular test for the presence of mecA. Two indices were developed to measure the comparison. One was a simple average (AVSSP) of sensitivity and specificity. The second method was based on rater agreement (k), which is the compatibility of scores obtained from two methods. The 13 susceptibility methods based on kappa and AVSSP are ranked from high to low efficiency. K measuring the rater agreement and including the concordant cells may be a better index.

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