JSM 2005 - Toronto

Abstract #304401

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 258
Type: Topic Contributed
Date/Time: Tuesday, August 9, 2005 : 10:30 AM to 12:20 PM
Sponsor: Section on Bayesian Statistical Science
Abstract - #304401
Title: A Simulation-based Approach to Bayesian Sample Size Determination: Examples and Issues
Author(s): Fei Wang*+
Companies: Boston University
Address: 200 Springs Road 152, Bedford, MA, 01730, United States
Keywords: Bayesian Sample Size Determination ; Hierarchical Modeling ; Multi-reader ROC analysis ; Model Performance Criterion ; Model Selection Criterion ; ALC
Abstract:

Sample size determination (SSD) is an important step in experimental design. Practitioners often face many uncertainties at the design stage, and Bayesian methods to determine sample sizes are ideally suited for this design aspect. First, valuable information usually is available prior to the experiment. It is helpful to incorporate this prior information at the design stage. In fact, "sampling prior" specifications in Bayesian SSD will arise in a "what if" spirit, allowing designers to assess Bayesian learning as a function of a sample size over a range of design situations. Second, it is sensible to average over the sample space because the sample has not yet been observed and the general principle of averaging over what is unknown applies. In this talk, we briefly review two types of Bayesian SSD approaches: simulation-based and formulated under Bayesian hierarchical modeling framework. We use examples from multireader study in evaluating diagnostic tests. Computational issues and software availability also will be addressed.


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Revised March 2005