JSM 2005 - Toronto

Abstract #304389

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 455
Type: Contributed
Date/Time: Wednesday, August 10, 2005 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #304389
Title: Hierarchical Latent Class Model for Evaluating Diagnostic Tests
Author(s): Alula Hadgu*+ and Nandini Dendukuri
Companies: Centers for Disease Control and Prevention and McGill University
Address: 1600 Clifton Road, Atlanta, GA, 30333,
Keywords: Diagnostic tests ; Bayesian inference ; Latent class model ; Conditional dependence ; Sexually transmitted disease
Abstract:

Studies of the validity of a new diagnostic test typically involve comparison of the new tests' results with an imperfect gold-standard test. Latent class models have been used widely for the analysis of such data, their advantage being that they do not assume 100% sensitivity and specificity of the imperfect test. While the traditional latent class model assumes different tests are conditionally independent given the latent true disease status, various extensions have been proposed to relax this unrealistic assumption. In this presentation, we describe another method for modeling conditional dependence between tests that separates groups of tests based on different biological phenomena. For the parameter estimation, as well as model checking and comparison, we use a Bayesian approach. The methods are illustrated using results from a study of diagnostic tests for a sexually transmitted disease.


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