JSM 2005 - Toronto

Abstract #304372

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.



The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

The Program has labeled the meeting rooms with "letters" preceding the name of the room, designating in which facility the room is located:

Minneapolis Convention Center = “MCC” Hilton Minneapolis Hotel = “H” Hyatt Regency Minneapolis = “HY”

Back to main JSM 2005 Program page
Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 477
Type: Topic Contributed
Date/Time: Thursday, August 11, 2005 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #304372
Title: Crossplatform Comparison of Microarray Gene Expression Intensities
Author(s): Kellie J. Archer*+ and Daniela Puiu and Catherine I. Dumur
Companies: Virginia Commonwealth University and Virginia Commonwealth University and Virginia Commonwealth University
Address: 14318 Beachmere Dr, Chester, VA, 23831, United States
Keywords: microarray ; cross-platform ; invariant ; errors-in-regression
Abstract:

Due to the growing number of microarray data repositories and the requirement on behalf of journals and granting institutions that data be made publicly available, it may be of interest to explore methods for merging microarray data across platforms for the purpose of performing statistical analyses. Therefore, this research investigated interlaboratory variability among RNA samples hybridized to three microarray platforms. Additionally, we explored the feasibility of combining intensities from three platforms for the purpose of conducting further analyses. Among a set of technical replicates, proportions of invariant features and the coefficient of variation were compared. For RNA extracted from breast and ovarian tumor samples, first platform-specific normalization methods were applied and then data were combined by scaling all arrays to a common baseline. Subsequent analyses were restricted to sequence-matched features. Because intensities resulting from each platform are subject to random measurement errors, errors-in-regression models were applied to compare the accuracy and consistency of gene expression measurements.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2005 program

JSM 2005 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2005