JSM 2005 - Toronto

Abstract #304363

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 53
Type: Topic Contributed
Date/Time: Sunday, August 7, 2005 : 4:00 PM to 5:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #304363
Title: The Role of Late Loss in Predicting Target Lesion Revascularization (TLR) in TAXUS Stented Coronary Lesions
Author(s): Zheng (Frank) Zhou*+ and Yongyi Yu and Peter Lam
Companies: Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
Address: One Boston Scientific Place, Natick, MA, ,
Keywords: Receiver Operation Characteristic ; Logistic Regression ; Logistic Risk Function ; In-Stent Late Loss ; Target Lesion Revascularization ; Restenosis
Abstract:

In typical coronary stent trials, several quantitative coronary angiography (QCA) parameters are measured by a core reading laboratory, both at baseline and followup. In-Stent Late Loss, defined as the difference in Minimum Lumen Diameter from immediately postprocedure to followup, is considered a benchmark measure of the effectiveness of the stent and an important variable to predict Target Lesion Revascularization (TLR) by some clinicians. Conventional thinking is that the smaller the Late Loss, the better. However, some clinicians consider modest Late Loss an essential part of remodeling during the healing process. In the TAXUS randomized trials, a logistic risk function showed the probability of TLR is low and only increases insignificantly when Late Loss is below a moderate level. Further analyses using ROC methods identified a level of moderate Late Loss that showed good sensitivity in discriminating TLR.

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Revised March 2005