JSM 2005 - Toronto

Abstract #304349

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.



The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

The Program has labeled the meeting rooms with "letters" preceding the name of the room, designating in which facility the room is located:

Minneapolis Convention Center = “MCC” Hilton Minneapolis Hotel = “H” Hyatt Regency Minneapolis = “HY”

Back to main JSM 2005 Program page
Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 134
Type: Contributed
Date/Time: Monday, August 8, 2005 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #304349
Title: Simultaneous Calibration and Peak-picking Algorithm for LC-ESI-FT-ICR Mass Spectrometry Data
Author(s): Jeanette Eckel-Passow*+ and Terry M. Therneau and Ann Oberg and David Muddiman and Christopher Mason
Companies: Mayo Clinic and Mayo Clinic and Mayo Clinic and Mayo Clinic and Mayo Clinic
Address: 200 First St SW, Rochester, MN, 55905,
Keywords: Proteomics ; Mass Spectrometry ; Calibration ; Peak Picking
Abstract:

Liquid chromatography electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (LC-ESI-FT-ICR-MS) is a potentially superior biomarker discovery platform because it offers high mass accuracy and mass precision as well as high resolving power over a broad mass-to-charge (m/z) range. As a result of the high resolving power in combination with the electrospray process, multiple charge states of the same molecular specie are inherent and easily identified in each spectrum. Utilizing information both within and across charge states, calibration without internal or external calibrants is achievable. A simultaneous calibration and peak-picking algorithm is presented that exploits peak-spacing information within an isotopic cluster of charge z0 and frequency shifts across isotopic clusters that represent the same molecular specie but differ in charge states by h, where h is an integer. The algorithm is performed entirely in the frequency domain, where both peak shape and peak width are known, thus requiring fewer and more stable parameters in comparison to algorithms performed in the m/z domain.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2005 program

JSM 2005 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2005