JSM 2005 - Toronto

Abstract #304329

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 138
Type: Contributed
Date/Time: Monday, August 8, 2005 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #304329
Title: A Note on Postrandomization Covariates Adjustment
Author(s): Minzhi Liu*+
Companies: Merck & Co., Inc.
Address: 126 E Lincoln Ave, Rahway, NJ, 07065, United States
Keywords: Causality ; Extrapolation ; Principle strata ; Proportion of treatment effect ; Simple Stratification ; Post-randomization adjustment
Abstract:

The adjustment for postrandomization variables has been widely used to obtain additional information in randomized experiments despite its conceptual and statistical difficulties. To enhance the chance of more appropriate postrandomization adjustment analyses and interpretation, this paper systematically summarizes the potential problems of the conventional regression-based postrandomization adjustment method on its reliability, precision, and causality and outlines available alternative methods that could possibly provide more powerful, less biased evaluation or more appropriate assessment for causality. A working example is used to illustrate the application of the different postrandomization adjustment methods.

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Revised March 2005