JSM 2005 - Toronto

Abstract #304278

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 366
Type: Contributed
Date/Time: Wednesday, August 10, 2005 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #304278
Title: Epidemiologic Comparison of Disease Incidence among Populations: The Person-years Approach
Author(s): V. Shane Pankratz*+ and Robert Vierkant and Shaun Maloney and Lynn Hartmann
Companies: Mayo Clinic and Mayo Clinic and Mayo Clinic and Mayo Clinic
Address: Harwick 7, Division of Biostatistics, Rochester, MN, 55905, United States
Keywords: epidemiology ; SMR ; expected events
Abstract:

In epidemiological studies, it often is of interest to compare disease incidence within a study cohort to that of a reference population. The person-years approach often is used to make and summarize such comparisons. The resulting Standardized Mortality Ratios (SMRs) summarize the degree to which observed cohorts differ from the reference population. While there have been criticisms of this method, there are few alternatives when one wishes to compare study groups with respect to their degree of deviation from population-based expectations. Our study of this topic is motivated by a desire to study the risks of breast cancer in women with a history of a benign breast biopsy relative to a reference population. In this study, followup data were obtained from a consecutive series of 9,086 women having had a benign breast biopsy. Women with a history of a benign breast biopsy had a SMR of 1.6 (95% CI: 1.5 - 1.7). We present an overview of the person-years method and demonstrate how estimates of per-subject-expected events may be used in the place of group-aggregated expected events.

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Revised March 2005