JSM 2005 - Toronto

Abstract #304026

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Activity Number: 200
Type: Contributed
Date/Time: Monday, August 8, 2005 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #304026
Title: Bedside Analysis of Cerebral Autoregulation in Very-low-birth-weight Infants
Author(s): Keith Williams*+ and C. Heath Gauss and Jeff Kaiser
Companies: University of Arkansas for Medical Sciences and University of Arkansas for Medical Sciences and University of Arkansas for Medical Sciences
Address: 4301 W Markham, Little Rock, AR, 72205, United States
Keywords: Cerebral Autoregulation ; Autoregressive Time series ; Robust Regression
Abstract:

Advances in obstetric and neonatal intensive care have led to dramatic increases in survival for the most premature and low-birth-weight infants. However, these infants are vulnerable to developing intraventricular hemorrhage and severe neurodevelopmental disabilities. In particular, experts believe disturbances of cerebral blood flow (CBF) regulation are associated with brain injury. Cerebral autoregulation is an essential physiologic process that maintains constant blood flow to the brain despite alterations in blood pressure. Thus, the determination of impaired CBF regulation during the first hours and days of life may prevent brain damage and is a valuable diagnostic to optimize clinical decisions in these vulnerable infants. We propose to develop a bedside diagnostic system, the Real-Time Autoregulation Diagnostic (RAD) system, that will incorporate several single clinical measures into statistical models. These models will in turn provide immediate information about a child's current autoregulation status. This system will aid clinicians in making quality intensive care decisions that will protect the neonatal brain.

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Revised March 2005