JSM 2005 Online Program

Abstract #303977

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	217
Type:	Topic Contributed
Date/Time:	Tuesday, August 9, 2005 : 8:30 AM to 10:20 AM
Sponsor:	Section on Statistics in Epidemiology
Abstract - #303977
Title:	Handling Missing Data in HIV Research
Author(s):	Ramses Sadek*+ and Roman Gvetadze
Companies:	Centers for Disease Control and Prevention and Northrop Grumman
Address:	1600 Clifton Road, Atlanta, GA, 30333, United States
Keywords:	missing data ; clinical trial ; HIV ; imputation
Abstract:	The objective of this study is to assess the methodological quality of handling missing data in randomized HIV research studies. We performed a systematic search of the Medline/PubMed indexed electronic database to identify all HIV-related clinical trial reports published in major peer-review medical journals during January 2000-December 2003. The identified original full-length manuscripts were subsequently hand-searched to assess how investigators dealt with missing data. A list of 522 HIV-related trial reports was obtained from 10 major medical journals. Most trials (77%) reported the presence of missing data. Of these, fewer than half (44%) reported on approaches to account for it. Methods often were poorly described. Many researchers ignored the missing data altogether, either by deleting subjects with missing data or relying on the default complete-case approach of the software package. Missing data are commonly encountered in HIV research and could play a crucial role in accurate interpretations of trial results.

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