JSM 2005 - Toronto

Abstract #303961

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 387
Type: Topic Contributed
Date/Time: Wednesday, August 10, 2005 : 10:30 AM to 12:20 PM
Sponsor: Section on Bayesian Statistical Science
Abstract - #303961
Title: A Bayesian SEIR Approach to Modeling Smallpox Epidemics
Author(s): Vanja Dukic*+ and Bret Elderd and Greg Dwyer
Companies: The University of Chicago and The University of Chicago and The University of Chicago
Address: MC2007, Chicago, IL, 60637, United States
Keywords: SIR models ; Bayesian epidemics ; smallpox ; vaccination
Abstract:

Much of the public-policy debate regarding smallpox vaccination has been focused on mass versus trace vaccination strategies; namely, whether the public can be better protected by vaccination of the entire population or of only those who have been in contact with infected individuals. Much of the previous work on smallpox epidemics has generally employed relatively complex deterministic models, with many biological parameters fixed, and focusing mostly on a single point estimate of the disease reproductive rate (the number of newly infected individuals arising from a single infected individual). We present a Bayesian analysis of multiple past smallpox epidemics. We obtain an estimate of the distribution of the disease reproductive rate rather than a point estimate, taking into account the uncertainty in other parameters in the model, and consequently allowing more informed decisionmaking with regard to the public policy of smallpox inoculation. This is joint work with B. Elderd and G. Dwyer. Although this research is supported by EPA STAR grant R-82940201-0, it does not necessarily reflect EPA views.


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Revised March 2005