JSM 2005 Online Program

Abstract #303782

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	359
Type:	Contributed
Date/Time:	Wednesday, August 10, 2005 : 8:30 AM to 10:20 AM
Sponsor:	General Methodology
Abstract - #303782
Title:	Evaluating the Performances of Several Approaches in the Identification of Differentially Expressed Probesets in Affymetrix GeneChip® Analysis
Author(s):	Fenghai Duan*+ and Heping Zhang
Companies:	Yale University and Yale University
Address:	470 Prospect Street, New Haven, CT, 06511, United States
Keywords:	affymetrix ; summarization ; non-summarization ; random
Abstract:	In this study, we compared the performance of several methods and algorithms in the identification of differentially expressed genes from the Affymetrix GeneChip® probe-level data. We mainly focused our comparisons on the differences between summarization approaches and nonsummarization approaches. The comparisons were made from several aspects. We first derived theoretical results about the significance testing using different approaches. Then, we proved our findings by a well-known Affymetrix benchmark dataset. Our conclusion is that the nonsummarization approach, which models the effects of probe and treatment as random, generally performs better than the summarization approaches and the fixed probe-effect, nonsummarization approach.

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