JSM 2005 - Toronto

Abstract #303729

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 312
Type: Topic Contributed
Date/Time: Tuesday, August 9, 2005 : 2:00 PM to 3:50 PM
Sponsor: Section on Bayesian Statistical Science
Abstract - #303729
Title: Bayesian Spatial Hierarchical Modeling for Asthmatic Patients and Nonasthmatic Adults
Author(s): Hyun Kim*+ and Robert Weiss and Jonathan Goldin
Companies: University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles
Address: 924 Westwood Blvd suite 650, Los Angeles, CA, 90024, United States
Keywords: Bayesian statistics ; spatial analysis ; Hierarchical model ; Asthma ; Computed Tomography
Abstract:

Asthma is the disease caused by air-trapping of the smooth muscle in the small bronchi of the lung. To assess regional air-trapping, high-resolution computed tomography (HRCT) measures and captures a lung into four lobes, nesting three segments in each lobe. We present an application of Bayesian hierarchical modeling to spatial analysis in the lung, incorporating normal random effect to each asthmatic patient or nonasthmatic adult. We use George and McCulloch's mixture modeling to detect the outlying cases and subject. The data were obtained from the baseline of FOREST and SINGULAIR study. We investigate a threshold of air-trapping to discriminate asthmatic patients and nonasthmatic adults with adjusting spatial effect in the lung. Then, we apply the analysis of sensitivity and specificity using the threshold.


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Revised March 2005