JSM 2005 Online Program

Abstract #303619

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	53
Type:	Topic Contributed
Date/Time:	Sunday, August 7, 2005 : 4:00 PM to 5:50 PM
Sponsor:	Section on Statistics in Epidemiology
Abstract - #303619
Title:	Receiver Operating Characteristic (ROC) Curve for Demographic Variable Dependent Diagnostic Method
Author(s):	Michael Lu*+ and Victoria Petrides
Companies:	Edwards Lifesciences and Abbott Laboratories
Address:	One Edwards Way, Irvine, CA, 92614, United States
Keywords:	diagnostics ; sensitivity ; specificity ; ROC curve ; cutoff
Abstract:	Traditional quantitative diagnostic tests often are determined based on a single cutoff. A test is considered "negative" or "positive" for a disease depending when the test result is greater or less than the cutoff. The cutoff value has a great impact on the interpretation of the diagnostic test and consequently patient diagnosis. To improve the clinical sensitivity and/or specificity of the test, one alternative to the traditional approach is to partition the population into several subpopulations based on certain correlated demographic variables and define different cutoff values for each subpopulation (multiple cutoff method). How does this multiple cutoff method impact the clinical sensitivity and specificity? How is the ROC curve impacted by multiple cutoffs? Can ROC analysis be used to determine if the multiple cutoff method provides meaningful benefit relative to the single cutoff method? Can ROC analysis help us determine optimal cutoffs for the multiple cutoff method? We will explore these and similar questions in the context of a quantitative diagnostic test.

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