JSM 2005 - Toronto

Abstract #303526

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 33
Type: Contributed
Date/Time: Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #303526
Title: A Flexible Monte Carlo Approach to Multipoint Linkage Analysis
Author(s): Wen-Chang Wang*+ and I-Shou Chang and Yuan-Chuan Chuang and Chao A. Hsiung
Companies: National Health Research Institutes and National Health Research Institutes and Ming Chuan University and National Health Research Institutes
Address: Division of Biostatistics and Bioinformatics, Zhunan Town, Miaoli County, 350, Taiwan
Keywords: IBD ; legal inheritance pattern ; legal ordered parental genotype ; Monte Carlo approach ; population haplotype frequency ; sequential imputation
Abstract:

This paper presents a new Monte Carlo approach to the problem of calculating the conditional probability of inheritance patterns given sibship genotype data, assuming the availability of parental level population haplotype frequencies and crossover distribution. By limiting the study to sibships, we propose a linkage analysis method that allows linkage disequilibrium among relevant genetic loci, can incorporate general crossover process model, and is computationally feasible. The cruxes of this approach are systematic ways to introduce probability distributions on the space of legal ordered parental genotypes consistent with sibship genotype and given inheritance pattern and on the space of legal inheritance patterns consistent with sibship genotype so as to apply importance sampling techniques for calculating various relevant probabilities. Using simulated data, we examine the performance of our method in terms of the accuracy in calculating the conditional probability of IBD sharing for sibpairs given the sibship genotype data. Comparisons with other methods will be reported.

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