JSM 2005 - Toronto

Abstract #303343

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number: 74
Type: Contributed
Date/Time: Sunday, August 7, 2005 : 8:00 PM to 9:50 PM
Sponsor: General Methodology
Abstract - #303343
Title: Predicting Time-to-clinical Stability and Length of Hospital Stay in Patients with Community-acquired Pneumonia
Author(s): Andrew S. LaJoie*+ and Rafeal De La Cruz and Douglas J. Lorenz and Julio A. Ramirez
Companies: University of Louisville and University of Louisville and University of Louisville and University of Louisville
Address: School of Public Health and Information Sciences, Louisville, KY, 40292, United States
Keywords: pneumonia ; time to clinical stability
Abstract:

Community-acquired pneumonia (CAP) is a prevalent condition that leads to hospitalization of 30% of infected patients. Patients often are given intravenous antibiotics until judged clinically stable and switched to oral antibiotics. Factors of time to clinical stability and length of hospital stay were studied in an international cohort of 1,645 CAP patients. Patients received either a single antibiotic or a combination of antibiotics. The data failed the proportional hazards assumption, hence parametric regression models were fit. The generalized gamma distribution provided the strongest fit to the data. Monotherapy patients reached clinical stability 22% faster than combination therapy patients. Admission to the ICU (34%), administration of antibiotics within eight hours of admission (14%), presence of bacterium (34%), and severe pneumonia (36%) contributed to longer times to clinical stability. Treatment type, disease severity, ICU admission, administration of antibiotics within eight hours, pleural effusion, and bacterium were predictive of longer hospital stays. Results show selection of an antibiotic regimen influences important clinical outcomes.

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Revised March 2005