JSM 2005 Online Program

Abstract #303146

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	106
Type:	Contributed
Date/Time:	Monday, August 8, 2005 : 8:30 AM to 10:20 AM
Sponsor:	Section on Statistics in Epidemiology
Abstract - #303146
Title:	Disease Clustering in an Analysis of Childhood Langerhans Cell Histiocytosis
Author(s):	Chih-Chieh Wu*+
Companies:	The University of Texas M. D. Anderson Cancer Center
Address:	Department of Epidemiology, Unit 1340, Houston, TX, 77030, United States
Keywords:	cluster ; Langerhans cell histiocytosis ; maximum ; minimum ; space-time clustering ; statistical test
Abstract:	Incidence patterns of point epidemics over time often contain periods of unusually low or high frequencies. Variations in incidence frequencies, which may be caused by changes in exposure to infectious or environmental agents, might permit important insights into the pathogenesis or etiology of a disease. We performed a systematic study of temporal clusters within spatial units with particular reference to a reported clustered incidence of Langerhans cell histiocytosis in children in Taiwan. We formulated and proposed new statistical tests for temporal clustering and space-time clustering based on the minimum frequency count in a unit of time and meaningful for the characteristic incidence patterns of the cases studied. Among the most widely applied methods are the Ederer-Myers-Mantel test and the scan test, both sensitive to the maximum frequency count in a unit of a time line. We comment on the data analysis of reported clusters and utilities of various tests.

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