JSM 2005 Online Program

Abstract #303072

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	33
Type:	Contributed
Date/Time:	Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #303072
Title:	Joint Localization of Two Linked Disease Susceptibility Genes Using Affected Relative Pairs
Author(s):	Wan-Yu Lin*+
Companies:	Graduate Institute of Epidemiology
Address:	National Taiwan University, No.3, Alley 23, Lane 236, Nanshan Rd.,, Taipei, International, 23565, Taiwan
Keywords:	generalized estimating equations ; affected relative pairs ; genes identical-by-descent ; multipoint analysis ; complex disease
Abstract:	For complex diseases, there are often more than one disease susceptibility gene locating in a chromosome region. We develop a method that can simultaneously estimate the positions of disease loci and the genetic effects using affected relative pairs. The expected genes IBD at the marker locus is a function of the distance between the marker and the susceptibility gene and the genetic effects. The method applies generalized estimating equations (GEE), which is robust to model misspecification. As the asymptotic distribution depends on the number of independent pedigrees, which is much less than the number of affected relative pairs, we apply the small-sample adjustments in using the sandwich variance estimator in generalized estimating equations proposed by Pan and Wall (2002).

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