JSM 2005 - Toronto

Abstract #303051

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 123
Type: Topic Contributed
Date/Time: Monday, August 8, 2005 : 10:30 AM to 12:20 PM
Sponsor: Section on Health Policy Statistics
Abstract - #303051
Title: A Comparison of Estimators of Population Slope under Informative Dropout
Author(s): Hai (Kevin) Lin*+ and Elizabeth Slate
Companies: The University of Texas M. D. Anderson Cancer Center and Medical University of South Carolina
Address: Science Park Research Division, Smithville, TX, 78957, United States
Keywords: longitudinal study ; population slope estimates ; informative dropout
Abstract:

We address estimation of the population slope of a longitudinal response in the presence of informative dropout. Traditional methods, such as generalized mixed model analyses, do not account for informative dropout and can produce biased estimates of the population slope. We use a simulation study to investigate the performance of four estimators of population slope under dropout of varying degrees of informativeness. The four estimators are the weighted and unweighted least squares methods, the empirical Bayes method (Mori et al.. 1992), and the informative right censoring adjusted estimator (IRCAE). The estimators are evaluated by MSE and bias. Of particular interest is the new comparison of the empirical Bayes estimator to IRCAE, for which our results show empirical Bayes with less bias and less MSE than IRCAE for the differing degrees of informativeness. However, both empirical Bayes and IRCAE estimates are more attractive and competitive than both the weighted and unweighted methods under informative censoring. We apply all four methods to data from two clinical trials.


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