JSM 2005 Online Program

Abstract #303006

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	188
Type:	Contributed
Date/Time:	Monday, August 8, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #303006
Title:	Probabilities of Spurious Connections in Gene Networks: Application to Expression Time Series
Author(s):	David Bickel*+
Companies:	Pioneer Hi-Bred International
Address:	7250 NW 62nd Avenue, Johnston, IA, 50131, United States
Keywords:	microarray gene expression ; gene network reconstruction ; multiple comparisons ; decisive false discovery rate (dFDR) ; systems biology ; time series
Abstract:	The decisive false discovery rate (dFDR) is exactly equal to a conditional probability without assuming independence or the randomness of hypothesis truth values. This property is useful not only in the common application to the detection of differential gene expression, but also in determining the probability of a spurious connection in a reconstructed gene network. Estimators of the dFDR can estimate each of three probabilities: (1) the probability that two genes that appear to be associated lack such association, (2) the probability that a time ordering observed for two associated genes is misleading, and (3) the probability that a time ordering observed for two genes is misleading, either because they are not associated or because they are associated without a lag in time. The first probability applies to both static and dynamic gene networks; the other two only apply to dynamic gene networks.

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