JSM 2005 - Toronto

Abstract #302821

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 34
Type: Contributed
Date/Time: Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #302821
Title: RNA Interference HTS: A New Biotechnology for Discovering a Novel Class of Drugs
Author(s): Xiaohua Zhang*+
Companies: Merck Research Laboratories
Address: Biometrics Research WP37T2, West Point, PA, 19486-0004, United States
Keywords: RNA interference ; RNAi drug ; High throughput screening ; Pharmacogenomics ; gene silencing ; Pharmaceutical Industry
Abstract:

RNA interference (RNAi) is a gene silencing phenomenon where an RNA introduced to a cell ultimately causes the degradation of the complementary cellular mRNA and leads to the silencing of gene activity. RNAi promises to be one of the most useful laboratory tools for gene function analysis and drug discovery. RNAi high throughput screening (HTS) is cropping up as a new biotechnology for discovering and developing drugs, which will lead to a novel class of drugs---RNAi drugs. In this presentation, I will introduce RNAi concept and mechanism and describe RNAi HTS technology and its applications in the pharmaceutical industry. I also will briefly demonstrate the visualization and analysis of RNAi HTS data in drug discovery.

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Revised March 2005