JSM 2005 - Toronto

Abstract #302646

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 4
Type: Invited
Date/Time: Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #302646
Title: Regional Admixture Mapping (RAM) and Structured Association Testing (SAT): A Unified Framework
Author(s): David B. Allison*+ and David T. Redden and T. Mark Beasley and José R. Fernández and Hemant Tiwari and Jasmin Divers and Robert P. Kimberly
Companies: University of Alabama at Birmingham and University of Alabama at Birmingham and University of Alabama at Birmingham and University of Alabama at Birmingham and University of Alabama at Birmingham and University of Alabama at Birmingham and University of Alabama at Birmingham
Address: 1665 University Boulevard, RPHB 327, Birmingham, AL, 35294-0022, USA
Keywords: regional admixture mapping ; ancestry ; structured association testing ; gene association
Abstract:

Recently, methods for estimating individual admixture at specific regions of the genome have been developed. So too have methods, for regional admixture mapping (RAM), that use these estimates to identify genomic regions harboring loci-influencing dichotomous phenotypes. Structured association testing (SAT) entails conducting tests unconfounded by admixture. We provide a unified framework for RAM and SAT in a least squares framework augmented with moment reconstruction to accommodate measurement error. We extend RAM methodology in several ways. We allow for greater ability to test dominance effects and fully control for confounding by ancestry. Additionally, we extend the method to a regression framework and show this easily accommodates both random and selective sampling, allows for either dichotomous or quantitative traits or both, allows for multivariate testing, allows for inclusion of covariates, allows for inclusion of related individuals, is predicted to be robust to distributional assumptions, and is computationally simple once the individual admixture estimates are calculated. All of these aspects increase flexibility, and some may increase power.

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Revised March 2005