JSM 2005 - Toronto

Abstract #302509

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 471
Type: Invited
Date/Time: Thursday, August 11, 2005 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract - #302509
Title: Transcription Regulation Networks
Author(s): Chiara Sabatti*+
Companies: University of California, Los Angeles
Address: 695 Charles Young Drive South, Los Angeles, CA, 90095-7088, USA
Keywords: Genome sequence ; microarray ; network ; transcription ; mcmc
Abstract:

Transcription is the first step of the process with which the static information coded in a genome determines the dynamic behavior of a living cell. The regulation of transcription is largely carried out by proteins that bind upstream of the controlled genes. Statistical analysis of the genome sequence can help determine the location of binding sites for such proteins, thereby identifying which genes they regulate and their possible interactions. Gene expression array experiments provide measurements of transcription levels and hence contain information on the transcription network. In this talk, I will present a series of statistical analysis of genome sequence and array data that shed light on the transcription network of E. Coli.

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Revised March 2005