JSM 2005 - Toronto

Abstract #302492

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 378
Type: Invited
Date/Time: Wednesday, August 10, 2005 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #302492
Title: Acute HIV Infection and Structured Treatment Interruption: Can Therapy Be Discontinued?
Author(s): Eric S. Rosenberg*+
Companies: Massachusetts General Hospital/Harvard Medical School
Address: Infectious Disease Division, Gray J504, Boston, MA, 02114,
Keywords: HIV ; Immunology ; Acute HIV infection ; Strucutred treatment interruption
Abstract:

Despite the advent of highly active antiretroviral therapy (HAART) and the remarkable decline in morbidity and mortality, the worlds' population continues to become infected at an alarming rate. For those individuals with access to HAART, the cost, toxicity, increase in drug resistance, unknown long-term side effects, and problems with adherence make the prospect of lifelong therapy daunting for some and impossible for most. Therefore, alternative treatment strategies such as a short course of treatment initiated during acute HIV infection followed by treatment cessation may have a substantial impact on controlling infection without the need for lifelong potent antiretroviral therapy. This talk will focus on the immunological, virologic, and clinical rationale for the treatment of acute HIV infection and Structured Treatment interruption as a potential adaptive treatment strategy in the management of HIV infection. The concepts presented will provide the scientific foundation to understand how the immune system typically fails in controlling HIV infection as well as provide potential immunotherapeutic strategies to ultimately control disease progression.

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Revised March 2005