JSM 2005 - Toronto

Abstract #302297

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 246
Type: Invited
Date/Time: Tuesday, August 9, 2005 : 10:30 AM to 12:20 PM
Sponsor: WNAR
Abstract - #302297
Title: Gene Expression and the Detection of Viral Contributions to Cancer
Author(s): Michael Newton*+
Companies: University of Wisconsin, Madison
Address: Department of Statistics, Madison, WI, 53792, USA
Keywords: gene expression ; microarray ; false discovery rate ; genomics
Abstract:

That viruses are a contributing factor in cancer biology is well known, but the precise nature of the viral contribution is not. In this paper, some of the statistical problems that arose in a study of Epstein-Barr virus and nasopharyngeal cancer are reviewed. One problem is to measure and calibrate associations between host and virus gene expression. Another problem concerns normalization of microarrays when there is a high degree of differential expression. A third problem concerns scoring gene annotations for enrichment of differential expression. There also is a problem of mapping differentially expressed genes onto the genome. Solutions to these problems are discussed.

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