JSM 2005 - Toronto

Abstract #302286

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 378
Type: Invited
Date/Time: Wednesday, August 10, 2005 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #302286
Title: Adaptive Multicourse Treatment Strategies in Two Oncology Trials
Author(s): Peter F. Thall*+
Companies: The University of Texas M. D. Anderson Cancer Center
Address: Biostatistics and Applied Math Dept, Box 447, Houston, TX, 77030, United States
Keywords: Adaptive design ; Bayesian design ; Clinical Trials ; Oncology
Abstract:

In this talk, two oncology trials conducted at M.D. Anderson Cancer Center in which each patient's therapeutic regimen included several courses are described. In each trial, the objective was to compare multicourse strategies, rather than individual treatments. The first study involved several two-course strategies for therapy of acute myelogenous leukemia (AML). Because AML is a rapidly fatal disease, each strategy was evaluated based on a trade-off between the probabilities of disease remission and death. The goal was to choose the best two-course strategy within each of several prognostic subgroups. The second trial included four treatments for prostate cancer given in various combinations in up to four courses of therapy. For each patient, a successful treatment was repeated, an unsuccessful treatment was replaced with a different treatment, and therapy was terminated after either two consecutive successes or a total of two failures. In both trials, each patient's initial treatment assignment was random, but treatments assigned to a patient in courses after the first depended on the patient's own previous treatments and outcomes, as well as other patients' data.

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Revised March 2005