JSM 2005 Online Program

Abstract #304826

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Activity Number:	183
Type:	Topic Contributed
Date/Time:	Monday, August 8, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #304826
Title:	Magnitude and Phase Modeling for fMRI Brain Activation
Author(s):	Daniel B. Rowe*+
Companies:	Medical College of Wisconsin
Address:	8701 Watertown Plank Road, Milwaukee, WI, 53226, United States
Keywords:	fMRI ; MRI ; neuroimaging ; brain activation ; functional imaging
Abstract:	In MRI and fMRI, images or voxel measurements are complex-valued at each time point. Recently, Rowe and Logan (2004) introduced a complex-valued fMRI magnitude activation model that specified that the voxel phase time courses were constant. Subsequently, Rowe and Logan (2005) generalized the model to have no restrictions on the phase time courses and derived the same regression coefficients and activation statistic as the usual magnitude-only data model. Recent findings by Hoogenrad (1998) and Menon (2002) indicate the voxel phase time course may exhibit task-related changes. A general complex fMRI activation model is introduced that describes both the magnitude and phase in complex data that can be used to specifically characterize task-related changes in both. Hypotheses regarding task-related magnitude and/or phase changes are evaluated using derived activation statistics. It also will be shown that the Rowe-Logan complex constant phase model strongly biases against voxels with task-related phase changes and the current general complex activation model can be cast to address several hypotheses of interest.

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