JSM 2005 - Toronto

Abstract #304697

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 225
Type: Contributed
Date/Time: Tuesday, August 9, 2005 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #304697
Title: Bayesian Analysis of Recurrent Event Data with Informative Censoring
Author(s): Nibedita Bandyopadhyay*+ and Ananda Sen
Companies: GlaxoSmithKline and University of Michigan
Address: One Franklin Plaza, Philadelphia, PA, 19101, United States
Keywords: Counting process ; Frailty ; Gibbs sampling ; Joint model ; Survival analysis
Abstract:

Recurrent-event setting, where the subjects experience multiple occurrences of the event of interest, is encountered commonly in many biomedical applications. In analyzing recurrent event data, noninformative censoring is employed often for the implementation of statistical methods. However, when a terminating event such as death serves as part of the censoring mechanism, validity of the censoring assumption may be violated because recurrence could be a powerful risk factor for death. We consider joint modeling of recurrent event process and terminating event under a Bayesian framework in which a shared frailty is used to model the association between the intensity of the recurrent event process and the hazard of the terminating event. Comparisons are made to other existing models for recurrent event data. Our proposed model is implemented to data from a well known cancer study.


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