JSM 2005 - Toronto

Abstract #304550

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 149
Type: Luncheons
Date/Time: Monday, August 8, 2005 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #304550
Title: Last-observation-carried-forward: Primary, Secondary, or Unnecessary Analysis?
Author(s): Bruce Binkowitz*+
Companies: Merck Research Laboratories
Address: Mail Drop RY34A316, Rahway, NJ, 07090, United States
Keywords: LOCF ; missingness ; imputation ; carry ; forward
Abstract:

Much has been written about the inadequacies of the last-observation-carried-forward method of imputation. Despite advancements in the understanding of missingness and methodogies to address this, LOCF is often still suggested, even requested, as part of a primary analysis to assess the effect of a new therapy. Do you think there are advantages to the approach that outweigh disadvantages, or is it time to put LOCF into the annals of statistical methodology history? Come to lunch to discuss with colleagues experiences involving the use and alternatives to this once (and still?) ubiquitous approach.

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Revised March 2005