JSM 2005 Online Program

Abstract #304502

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	183
Type:	Topic Contributed
Date/Time:	Monday, August 8, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #304502
Title:	Block Kriging in SPECT/PET Brain Images: Defining Blocks
Author(s):	Jeffrey Spence*+ and Patrick Carmack and Richard Gunst and William R. Schucany and Qihua Lin
Companies:	The University of Texas Southwestern Medical Center at Dallas and The University of Texas Southwestern Medical Center at Dallas and Southern Methodist University and Southern Methodist University and Southern Methodist University
Address:	5323 Harry Hines Blvd, Dallas, TX, 75390-8896, United States
Keywords:	SPECT ; PET ; block ; kriging ; spatial ; brain
Abstract:	Recent methods in SPECT and PET brain imaging analyses take advantage of spatially correlated voxels by modeling regional correlation structure prior to kriging within voxel clusters or blocks. Traditional statistical methods can be applied to uncorrelated block averages, which require constraints on how blocks are defined. Convexity is required if the distance metric is Euclidean, and block size is determined by the extent of spatial correlation as measured by a semivariogram range parameter. In addition, blocks are defined similarly for each subject in a multisubject study. Other than these minimal constraints, the definition of a block can be arbitrary, especially when no anatomical or functional basis exists to guide a proper definition. In this study, sensitivity analyses are performed to investigate optimality properties of blocks to be used in a spatial analysis of brain images. Examples from a SPECT study of Gulf War veterans are given.

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