JSM 2005 - Toronto

Abstract #304307

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number: 15
Type: Topic Contributed
Date/Time: Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #304307
Title: Case Example of the Use of Multiple Logistical Regression Model with Correlated Predictors
Author(s): Peter Lam*+ and Hong Wang and Joerg Koglin and Mary Russell
Companies: Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation and Boston Scientific Corporation
Address: One Boston Scientific Place, Natick, MA, 01760, United States
Keywords: Clinical Trial ; Multiple Logistic Regression ; Multicollinearity
Abstract:

Drug-eluting stents (DES) have been shown to be more effective in the reduction of target lesion revisualization (TLR) compared to bare metal stents (BMS), especially in patients with small vessels and long lesions. One European country provides DES reimbursement for patients with small vessels and long lesions, but denies DES reimbursement for diabetic patients, arguing that diabetes is no longer an independent risk factor once vessel size and lesion length are included in the multiple regression model for TLR due to the multicollinearity among the predictor variables. A multiple logistic regression for TLR with predictors of treatment (DES/BMS), lesion length, vessel diameter, and diabetic status from the pooled database of four randomized DES trials confirmed the significant marginal benefit in TLR reduction through 12 months for diabetic patients. Provided treatment, lesion length, and vessel diameter were included in the model. In conclusion, there is a significant clinical benefit associated with DES compared to BMS with respect to 12-month TLR reduction in patients with or without diabetes and with varying vessel diameter and lesion length.

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Revised March 2005