JSM 2005 Online Program

Abstract #304114

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	34
Type:	Contributed
Date/Time:	Sunday, August 7, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biopharmaceutical Section
Abstract - #304114
Title:	Zyomyx Protein Biochip: Normalization and Analysis
Author(s):	Lisa Ying*+ and Chidambaram Ramachandran and Ellen Rohde and Linda Kochanski and Dita Rasper and Stephanie Tuck and Vladimir Svetnik
Companies:	Merck & Co., Inc. and Merck & Co., Inc. and BiogenIdec and Merck & Co., Inc. and Merck & Co., Inc. and Merck & Co., Inc. and Merck & Co., Inc.
Address:	RY33 300, Rahway, NJ, 07065, United States
Keywords:	protein microarray ; normalization ; hybrid transformation ; zyomyx
Abstract:	Protein microarray technology holds a great potential for the identification and quantitation of protein changes in preclinical and clinical proteomics. Zyomyx Protein Profiling Biochip System is one of a few fully operational automated platforms of protein microarray technologies available to date. Zyomyx Biochips are available for profiling of human and murine cytokines (total 29 cytokines can be analyzed simultaneously). We have done experiments to validate this technology. Based on the data and the nature of the chip design, we have established protocols for normalization, including background correction, hybrid transformation, and quantitation. Data from the use of the technology to determine the minimum and maximum concentrations of cytokines that can be determined appropriately will be shown. This technology has been used to identify treatment-related changes in cytokines. In addition, examples such as the use of this technology to estimate IC50 for cytokines inhibited by the compounds will be shown.

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