JSM 2005 Online Program

Abstract #304110

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

The Program has labeled the meeting rooms with "letters" preceding the name of the room, designating in which facility the room is located:

Minneapolis Convention Center = “MCC” Hilton Minneapolis Hotel = “H” Hyatt Regency Minneapolis = “HY”

Back to main JSM 2005 Program page

Legend:

= Applied Session,

= Theme Session,

= Presenter

Activity Number:	149
Type:	Luncheons
Date/Time:	Monday, August 8, 2005 : 12:30 PM to 1:50 PM
Sponsor:	Biopharmaceutical Section
Abstract - #304110
Title:	Sample Size Reestimation and Other Innovative Adaptive Designs in Clinical Trials
Author(s):	Jeff Maca*+
Companies:	Novartis Pharmaceuticals
Address:	One Health Plaza, East Hanover, NJ, 07936, United States
Keywords:	Adaptive ; Sample size re-estimation ; Trial Design
Abstract:	When designing clinical trials, information about the characteristics of the treatment may not be available at the desired level of precision, or there may be no directly relevant information available. This lack of information could cause a study to be designed with incorrect trial parameters or assumptions, and could cause a study to fail even in the case of a beneficial treatment. Therefore, it could be considered advantageous to design a study in such a way that the design parameters can adapt or change as information is gathered pertaining to the effect of the treatment. One clear adaptation would be to adjust the sample size as parameter estimates become updated with information collected from the study. However, there could be many other adaptations, such as changing hypothesis, treatments, or number of treatment groups. The practical issues pertaining to designing and running such a trial will be discussed.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2005 program