JSM 2005 Online Program

Abstract #303433

This is the preliminary program for the 2005 Joint Statistical Meetings in Minneapolis, Minnesota. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2005); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

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Activity Number:	309
Type:	Topic Contributed
Date/Time:	Tuesday, August 9, 2005 : 2:00 PM to 3:50 PM
Sponsor:	Biometrics Section
Abstract - #303433
Title:	A Comparison of EuroQoL and SF-36 Utilities in End-stage Heart Failure Patients
Author(s):	Huiling Li*+ and Daniel Heitjan
Companies:	Merck & Co., Inc. and University of Pennsylvania
Address:	UNA-102, PO Box 4, West Point, PA, 19486, United States
Keywords:	EuroQoL ; Preference-based instrument ; QALYs ; SF-6D ; Utilities
Abstract:	There are disparities among the preference-based (or utility-based) instruments produced by various methods. Consequently, there is no single preferred preference-based measure of health-related quality of life to estimate quality-adjusted life years (QALYs). SF-6D is a recently developed preference-based measure of health derived from SF-36. It permits a transformation from SF-36 data to preference scores to calculate QALYs. We derive a preference-based single index from the SF-6D using a utility scoring algorithm (Brazier et al. 2002) among end-stage heart failure patients in the REMATCH clinical trial. We compare the resultant preference-based index to the EuroQoL visual analogue scale (VAS) score in order to evaluate the reliability and validity of the SF-6D measures. Our study indicates the two methods do not give comparable results. SF-36 preference score has a much narrower range than the EuroQol preference scores, and it does not have values at the lower end of the health state scale, which suggests a limited use for this instrument in patients with end-stage heart failure.

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