JSM 2005 - Toronto

Abstract #303385

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Activity Number: 487
Type: Contributed
Date/Time: Thursday, August 11, 2005 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #303385
Title: Power of a Test with Multiple Subtests in a Longitudinal Data Study
Author(s): Jiannong Wang*+
Companies: Novartis Pharmaceuticals
Address: One Health Plaza, East Hanover, NJ, 07936, United States
Keywords: Power ; Longitudinal study ; simulation
Abstract:

In a longitudinal study, the measurements will take place in a series of consecutive visits or time points. In this paper, we discuss the study with the primary objective of doing a comparison at all consecutive time points. The test proceeds to the next time point if, and only if, the test at the current time point is statistically significant. As the primary objective has consisted of multiple subtests, the power of the test will not be straightforward for a statistician. We have investigated the power of the test under several assumptions of response curves. Sample sizes are provided based on the simulation, and assumptions of response curves are compared with the sample sizes from some simple tests.

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Revised March 2005