JSM 2005 - Toronto

Abstract #303302

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 482
Type: Contributed
Date/Time: Thursday, August 11, 2005 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #303302
Title: Estimating QTL Parameters under Selective Genotyping
Author(s): Jaya Satagopan*+ and Saunak Sen and Gary Churchill
Companies: Memorial Sloan-Kettering Cancer Center and University of California, San Francisco and The Jackson Laboratory
Address: 307 East 63rd Street, New York, NY, 10021, United States
Keywords: selective genotyping ; conditional likelihood ; qtl
Abstract:

Identifying genetic loci associated with quantitative traits is often a multistep process. Selective genotyping is an outcome-based sampling approach whereby subjects with extreme trait values are genotyped more often than intermediate ones. When subjects are selectively sampled in this manner, a conditional likelihood is a natural way to estimate model parameters. This talk examines the efficiency of selective genotyping by evaluating the properties of the model parameters and the variance estimates derived using a conditional likelihood.

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Revised March 2005