JSM 2005 - Toronto

Abstract #302883

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 192
Type: Contributed
Date/Time: Monday, August 8, 2005 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #302883
Title: The Construction of Composite Scores in Analgesia Studies
Author(s): David Bristol*+ and Genming Shi
Companies: Purdue Pharma LP and Schering-Plough
Address: 59 Cottonwood Court, Monmouth Junction, NJ, 08852, United States
Keywords: composite score ; multiple endpoints
Abstract:

In analgesia studies, pain intensity ratings often are used to assess the efficacy of treatments. However, when some patients use rescue medication, it is desirable to consider pain intensity rating and the amount of rescue medication simultaneously as endpoints in evaluating the treatment effects. Composite scores of pain intensity rating and amount of rescue medication can be constructed and used to perform statistical tests for between-treatment comparisons. In this paper, derivation of the composite scores and advantages of their use are discussed. The results will be demonstrated through simulations.

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