JSM 2005 - Toronto

Abstract #302654

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 383
Type: Invited
Date/Time: Wednesday, August 10, 2005 : 10:30 AM to 12:20 PM
Sponsor: IMS
Abstract - #302654
Title: First Entrance of DNA into a Nanopore
Author(s): Charles Hagwood*+ and Charles Hagwood
Companies: National Institute of Standards and Technology and National Institute of Standards and Technology
Address: Statistical Engineering Division, Gaithersburg, MD, 20899,
Keywords: nanopores ; stochastic differential equations ; transition probability ; first passage
Abstract:

The mechanics of DNA transport through nanopores has attracted considerable attention because of its relevance to explaining cell behavior and its technological importance (e.g., DNA sequencing). Single strain DNA is modeled as a flexible polymer using Zimm's model for hydrodynamic interaction. The motion of the DNA in a box with all sides reflecting, except one absorbing side on which the pore resides, is modeled using the Langevin equation. The transition probability is derived using the Fokker Planck equation. From this, the probability that the DNA polymer is found at the entrance to the pore is computed. First entrance times also are computed.

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