JSM 2005 - Toronto

Abstract #302404

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 42
Type: Invited
Date/Time: Sunday, August 7, 2005 : 4:00 PM to 5:50 PM
Sponsor: Biometrics Section
Abstract - #302404
Title: Integrating Pathway Information in DNA Microarray Data Analysis
Author(s): Mahlet G. Tadesse*+
Companies: University of Pennsylvania
Address: 604 Blockley Hall, Philadelphia, PA, 19104, United States
Keywords: Bayesian inference ; biological pathways ; DNA microarray analysis ; MCMC methods ; variable selection
Abstract:

Current methods for analyzing DNA microarray data do not incorporate existing biological information. A large amount of knowledge, however, has been accumulated over the years and its integration in the analysis could improve the search for biologically meaningful markers. We propose a method to evaluate gene expression profiles in the context of known biological pathways by extracting the information from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Finally, we illustrate the procedure using DNA microarray data from a breast cancer study.

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Revised March 2005