JSM 2005 - Toronto

Abstract #302371

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 381
Type: Invited
Date/Time: Wednesday, August 10, 2005 : 10:30 AM to 12:20 PM
Sponsor: General Methodology
Abstract - #302371
Title: Bounds on Causal Effects in Three-arm Trials with Noncompliance
Author(s): Jing Cheng*+ and Dylan Small
Companies: University of Pennsylvania and The University of Pennsylvania
Address: 423 Guardian Drive, 503 Blockley Hall, Philadelphia, PA, 19104-6021,
Keywords: three-arm trials ; noncompliance ; causal effect ; principal strata ; bounds ; confidence interval
Abstract:

Three-arm trials are common in practice. In these trials, the average causal effects of treatments within principle strata are of interest for several reasons. Unfortunately, even with the usual assumptions, the average causal effects of treatments within principal strata are not point-identified. However, the observable data does provide useful information about the bounds of the identification regions of the parameters of interest. Under two sets of assumptions, we derive sharp bounds for the causal effects within principal strata and construct confidence intervals to cover the identification regions. The methods are illustrated by an analysis of data from a randomized study of treatments for alcohol dependence.

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Revised March 2005