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Legend:  = Applied Session,
 = Theme Session,
 = Presenter
FRY = Fairmont Royal York, ICH = InterContinental Hotel, TCC = Metro Toronto Convention Center
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CE_10C
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Sun, 8/8/04, 8:15 AM - 4:15 PM
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FRY-Alberta
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Design and Analysis of Gene Expression Studies Using Microarrays (1Day Course) - Continuing Education - Course
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ASA
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Instructor(s): Robert J. Tempelman, Michigan State University, Guilherme J.M. Rosa, Michigan State University
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Many applied statisticians collaborating with genomic researchers have been overwhelmed by a plethora of conflicting recommendations on design and analysis that pervade the microarray data analysis literature. Our course integrates fundamentally important concepts in experimental design and mixed model ANOVA in helping statisticians and their collaborators evaluate design and power considerations for their own studies. The distinction between experimental replication and technical replication or subsampling in these evaluations is particularly addressed as these two levels of replication are often confused with each other in many power and analysis methods papers. Our course is based on materials that we have presented in 4+ different national and international workshops, primarily to biologists. Therefore, our presentation emphasizes sources of variation that have been recognized by biologists and need to be considered by their statistical collaborators. Along those lines, a basic introduction to genomics research with a general overview of different microarray technology platforms with implications for design and analysis is provided as well. A fundamental background in experimental design is required whereas training in mixed model analysis and some experience with SAS software is desirable but not required.
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