JSM 2004 - Toronto

Abstract #302159

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Activity Number: 437
Type: Contributed
Date/Time: Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #302159
Title: A New Exact Test for Homogeneity of Risk Difference
Author(s): Colleen Kelly*+ and Karen Lo
Companies: San Diego State University and San Diego State University
Address: Dept. of Mathematics and Statistics, San Diego, CA, 92182-7720,
Keywords: multicenter clinical trials ; risk difference ; permutation test ; bootstrap test ; Type I error
Abstract:

A new exact test for homogeneity of risk differences is proposed. Our proposed methodology is to develop randomization and bootstrapped tests to improve the performance of the asymptotic tests discussed in Lui and Kelly (2000). We first focus on a matched pairs design and then extend the test to the unmatched case. We investigate the performance of these new exact tests through Monte Carlo simulations, and compare their performance of that of the weighted least squared test statistic, which has an asymptotic chi-square distribution. In particular, we are interested in the performance when each center has a small sample size.

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Revised March 2004