JSM 2004 - Toronto

Abstract #302023

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Activity Number: 90
Type: Contributed
Date/Time: Monday, August 9, 2004 : 9:00 AM to 10:50 AM
Sponsor: General Methodology
Abstract - #302023
Title: Design and Analysis of Split-mouth Dental Trials
Author(s): Donald E. Mercante*+
Companies: LSU Health Sciences Center
Address: School of Dentistry, Box 137, New Orleans, LA, 70119,
Keywords: split-mouth design ; incomplete block design ; cross-over ; correlated data
Abstract:

Studies in which the person is subdivided into several smaller experimental units are common in dentistry. In particular, regions of a mouth, such as opposing upper quadrants, are randomly assigned a treatment or intervention and the response measured. Sampling plan may include obtaining subexperimental level information at several specific sites within each quadrant or experimental unit. The overall goal of these trials is to provide increased efficiency with respect to whole-mouth (i.e., parallel group) trials. These designs are similar in nature to cross-over designs but without washout periods. A possible advantage being that the trials can be conducted in less time, or with fewer patients than either a parallel or crossover trial. However, if carry-over effects are present, then treatment effects are potentially biased. Additionally, in many dental trials there are more treatments than available experimental units, thus necessitating the use of an incomplete block design. We focus on the design and analysis of split-mouth dental trials when using incomplete block designs. Issues of estimability, confounding, and efficiency of these designs are addressed.

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