JSM 2004 - Toronto

Abstract #301664

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Activity Number: 200
Type: Contributed
Date/Time: Tuesday, August 10, 2004 : 9:00 AM to 10:50 AM
Sponsor: Biometrics Section
Abstract - #301664
Title: Estimation of Age-Specific Sensitivity and Sojourn Time in Breast Cancer Screening
Author(s): Xiuyu Cong*+ and Yu Shen
Companies: Rice University and University of Texas M. D. Anderson Cancer Center
Address: 6100 Main St. MS-138, Houston, TX, 77005,
Keywords: age-specific estimation ; screening sensitivity ; sojourn time distribution ; breast cancer screening
Abstract:

The main objective of this research is to quantitatively model the effect of age at detection on screening sensitivity and sojourn time distribution in breast cancer screening trials. Building on the modeling framework of Shen and Zelen (1999), we proposed parametric models to associate the age at detection with screening sensitivity and sojourn time distribution and obtained the corresponding parameter estimates using the maximum likelihood methods. The AIC criterion was used in the process of model selection. Extensive simulation studies show that the estimators have reasonable accuracy and the model selection criterion works well. The proposed methods are illustrated using data from two large breast cancer screening trials. The results based on these two trials show that the screening sensitivity increases with age at detection.

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