JSM 2004 - Toronto

Abstract #301139

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Activity Number: 155
Type: Contributed
Date/Time: Monday, August 9, 2004 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #301139
Title: Analysis of cDNA Microarray Gene Expression Data Using GenePlus
Author(s): Juan (Joanne) Zhang*+ and Yi Tsong and Lue Ping Zhao
Companies: U.S. Food and Drug Administration and U.S. Food and Drug Administration and Fred Hutchinson Cancer Research Center
Address: , , MD, 20878,
Keywords: microarray ; gene expression ; GenePlus
Abstract:

Microarray technology provides a global overview of thousands of different genes simultaneously. OPS/DAPR/FDA conducted a cDNA microarray experiment including six microarry chips. Each chip includes treated and controlled samples, which are from kidney tissues of rats. The primary objective is to identify genes that are differentially expressed between treated and controlled groups. We approach this goal from two different angles. One way is to identify those genes which have high mean differences based on six chips between two groups. Another way is to identify those genes that are consistently up regulated or down regulated based on each experiment among six chips. We apply six statistical analysis strategies to the dataset using GenePlus software.


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