JSM 2004 - Toronto

Abstract #300512

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Activity Number: 117
Type: Contributed
Date/Time: Monday, August 9, 2004 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistical Consulting
Abstract - #300512
Title: Comparing Treatments in In-vivo Drug-Screening Experiments
Author(s): Leah Martell*+
Companies: Novartis
Address: One Health Plaza, East Hanover, 07963,
Keywords: drug-screening ; multiple comparisons ; parametric, nonparametric tests
Abstract:

The in-vivo drug-screening experiments impose a particular set of issues like small sample size, deviation from normality and equal variance, large number of treatments, requiring a tailored approach when comparing different groups. The large body of literature addresses the subject in a more general context which is sometimes not pertinent in this circumstance. Based on a survey of relevant literature I provide a list of applicable strategies, as well as a list of recommendations reflecting the current understanding of the problems. The focus is on all pairwise comparisons for continuous data and independent samples. Examples are taken from different drug treatments with a single endpoint measurement.


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